Mathew George
Pushpagiri College of Pharmacy, India
Title: Pharmacological screening of oxazines for epilepsy
Biography
Biography: Mathew George
Abstract
Oxazines are six membered heterocyclic compounds with oxygen and nitrogen as heteroatoms in the ring. Many isomers exist depending on the relative position of the heteroatoms and relative position of the double bonds. Oxazine derivatives are promising heterocyclic with extensive biological properties. Oxazine derivatives have been reported to possess antifungal, antibacterial, cytotoxic, antiviral and analgesic activity. Twenty five oxazines derivatives synthesized and all structures characterized spectrally, CHN analysis done and subjected to screen for anticonvulsant property by two methods classical maximal electroshock (MES) and by chemically induced methods. Epilepsy is featured by recurrent unprovoked seizures. Acute toxicity of the compounds studied and experiments proceeded with safe dose. The structure-activity relationship among these compounds has also been discussed. This study highlighted the properties of new compounds with different functional groups exert promising antiepileptic properties, which may be more effective and selective, and possibly with less side effects. Compounds with halogen exhibited more activity.